Word: repressors
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...fellow at Harvard, Ptashne rose to fame after isolating the repressor of lambda phage virus. The lambda virus is able to remain dormant in E. coli bacteria because its repressor binds to the viral DNA, preventing the expression of the genes necessary for viral replication...
...repressor motif is used in gene regulation in many other organisms, but for years, prominent researchers had failed to isolate a repressor, Ptashne says...
...focus is proving it is a repressor, and to understand what the gene has to do with control of the white blood cell," he said. "We hope to use the white blood cell as s model system and also to use it to understand what [CDP] does in early development...
About three months ago he discovered that two proteins of the virus bind to the host cell's DNA and determine the cell's growth pattern. One protein activates the genes that trigger destructive growth, while the other, the repressor protein counteracts the growth...
...Harvard researchers concluded that carcinogens split repressor proteins in two, eliminating resistance to destructive growth, Ptashne said...