Word: reprogramming
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...churn out their proteins for a only brief period of time, so using less virulent viruses, such as the adenovirus (responsible for the common cold) or simply saturating the cell with growth factors and nutrients directly may work. "Technically, it should be possible to introduce genes or protein to reprogram cells," says Hochedlinger...
...other concern is perhaps more daunting-two of the four factors that can turn back the clock on adult cells so efficiently are known to cause cancer. One, in fact, was the first gene discovered to cause cancer in mice. "Figuring out how to reprogram cells without directly exposing the cell to the cancer-causing effects of these genes is a major area of scientific activity, and would have to occur before we could consider using similar factor in humans," says Eggan...
Most of the errors in reprogramming, scientists say, can be traced to a process known as DNA methylation. During normal development, molecules called methyl groups attach themselves to DNA in precisely timed patterns that regulate which genes are expressed at which times. During cloning, however, those patterns are not always reconstructed in exactly the same way. It's a bit like taking all the words in a novel, jumbling them up and then trying to re-create the original book, putting sentences, pages and chapters back in the right order. The chances of that happening with 100% accuracy are minuscule...
...similar deal with Time Warner, owner of TIME, which still carries CCTV International on its cable systems but has sold its controlling stake in a Chinese channel.) As part of News Corp.'s commitment to the venture, it hired Terenzio to spend a few months a year helping reprogram CCTV-which once railed against "hegemonic powers" like the U.S.-to appeal to American audiences...
...change ago by a bunch of people who figured they'd start afresh on a brand-new, spotless continent. Maybe that's why we think we can go overseas and build brand-new nations from scratch--hey, that's how we did it, right? Wipe the slate clean and reprogram the patient? But as Joel discovers in Eternal Sunshine of the Spotless Mind, it's not quite that simple: however much you wipe and wipe that slate--out, damned spot!--something, some mysterious, unerasable palimpsest, remains behind...