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...clustered near a gene called TERC, which is already known to play a role in the production of an enzyme called telomerase. Telomerase repairs telomeres when they shorten. "That was very exciting for us," says Nilesh Samani, a cardiologist at the University of Leicester who co-led the research, which was published last week in Nature Genetics. "It gave us great confidence that we identified genetic variants on a pathway we already know is associated with telomere length...
...Samani also says the telomere research offered no quick fixes and that telomere-based treatments were still a long way off. The reason for this is that telomeres - while potentially lowering the risk of heart disease - play a role in the development of cancer cells. "We all probably develop cancer cells that don't get past a few replications because of the effect of normal telomere shortening. If you make cells immortal by allowing them to replenish their telomeres, you may raise the risk of many nasty cancers considerably...
Nevertheless, biologists have been suggesting for years that species across the board are likely to come under some metaphorical heat as the actual temperature rises - and this new and exhaustive piece of research is at the very least perfectly consistent with those predictions...
Overall, the DSM-5 is shaping up to be a much better reference than its predecessor. There will be months of negotiations - anyone can register at dsm5.org to comment, and consumer groups, day-to-day therapists, research psychologists and many others will have a say. But give the APA one thing: it seems to acknowledge, finally, that it is not the sole arbiter of what makes a person crazy...
...Even by the opulent standards of the gaming world, analysts say these are giant sums. "The Singapore casinos are by far the most expensive ones in the region," says Gabriel Chan, head of Asian gaming research for Credit Suisse, who points out that an average casino in Macau costs roughly half as much. The Venetian in Las Vegas, completed by Adelson more than a decade ago, cost roughly $1.5 billion - less than a third of his current Singapore project...