Word: researching
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Dates: during 2000-2009
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...start with - sharper minds, broadly - may be better able to withstand the ravages of age. "In some ways, you could think of it like a trained athlete who might be able to resist some atherosclerosis of the heart," explains Dr. Bradley Hyman, director of the Massachusetts Alzheimer's Disease Research Center and a professor of neurology at Harvard Medical School...
...memory loss - also have enlarged neurons, compared with patients who suffer cognitive impairment. Dr. Diego Iacono, a neuropathology fellow at Johns Hopkins School of Medicine and the future director of the Brain Bank at Sweden's Karolinska Institute, conducted several such studies in predominantly male populations, but his latest research, the study published in Neurology, demonstrates the same patterns in an entirely female population - of nuns. (See pictures of the sisters of Summit...
...exactly the brain builds up resistance to Alzheimer's is, of course, the central question driving legions of researchers. Are some people's brains capable of building detours around damaged neural circuits? Is there a gene that may help certain people rebuild and repair damaged brain tissue better than others can? Iacono suggests that's a strong possibility, pointing to the presence of one particular gene, APOE2, in 30% of patients with asymptomatic Alzheimer's. The next step in his research, he says, is to understand how this gene works...
...research, conducted as part of the National Institute of Aging Interventions Testing Program, took place at three separate test sites and involved nearly 2,000 genetically similar mice. Trials began when mice were about 600 days old - well into middle age, at a stage roughly equivalent to 60-year-old humans. (See the top 10 medical breakthroughs...
Rapamycin's life-extending effect has been demonstrated by other researchers in past studies of worms, fruit flies and yeast; the drug appears to interfere with a similar cellular process in those species too. "I think this is a big leap from those invertebrate species to mammals," says Strong, who is also a senior research scientist for the Department of Veteran Affairs. "This gives us a good idea that perhaps it would work in humans...