Word: respondents
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Dates: during 2000-2009
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...genetic research helps explain why some smokers respond better to certain smoking-cessation programs than others, according to scientists at Duke University and the National Institute on Drug Abuse...
Reporting this week in the Archives of General Psychiatry, scientists describe for the first time a set of genes, about 100 in all, that seem to predict how well a smoker will respond to two different types of quitting programs - nicotine replacement or bupropion (Zyban). Nicotine-replacement methods, including the patch, pill and gum, work by weaning the smoker off nicotine gradually, usually over a period of weeks or months. Bupropion, on the other hand, is an antidepressant, which does not contain nicotine; instead, it works to curb nicotine cravings by interfering with the reward circuit in the brain, where...
Rose found that people with genes that more efficiently code for bupropion breakdown respond better to the drug, while people with genetic variants that improve cell communication - also called adhesion - seem to have an easier time overall in quitting. That makes sense, since addictive behaviors such as smoking are deeply ingrained in the brain, and are strongly tied to social and environmental triggers. That network of neural connections, once cemented, is tough to break. But having certain versions of genes that facilitate neural flexibility - easing the uncoupling of certain brain connections and replacing them with new habits - could, says Rose...
...York and New Jersey, which owns the Trade Center site, insisting on the need for more security in the parking garage. Their recommendations, which would have been expensive, were ignored, according to James B. Stewart's biography of Rescorla, Heart of a Soldier. (The Port Authority did not respond to my requests for comment...
Rescorla felt it was foolish to rely on first responders to save his employees. His company was the largest tenant in the Trade Center, a village nestled in the clouds. Morgan Stanley's employees would need to take care of one another. He ordered them not to listen to any instructions from the Port Authority in a real emergency. In his eyes, it had lost all legitimacy after it failed to respond to his 1990 warnings. And so Rescorla started running the entire company through his own frequent, surprise fire drills. He trained employees to meet in the hallway between...