Word: retinitis
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Dates: during 1990-1999
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...already been proved. Says Dr. Martin Raber, physician in chief of the M.D. Anderson Cancer Center in Houston: "It is accepted practice that once a drug is FDA-approved it can be freely used." But the FDA gets nervous when a drug's unapproved uses overshadow its original purpose. Retin-A cream, for example, was approved by the FDA for the treatment of acne in 1971, but then, much to the FDA's consternation, it was widely prescribed to smooth wrinkles caused by aging and overexposure...
...Johnson & Johnson subsidiary says it will plead guilty tomorrow to obstructing a federal probe of how it marketed Retin-A, an acne drug commonly prescribed as a wrinkle remover. The firm, Ortho Pharmaceuticals of Raritan, N.J., agreed to pay $7.5 million in fines and dismiss three senior employees who shredded documents sought by investigators. The U.S. Food and Drug Administration launched its investigation in 1991, concerned that Ortho had been promoting Retin-A for a non-approved use as a wrinkle cream...
...antiwrinkle cream Retin-A may have an important side effect: it reverses a condition that sometimes leads to cervical cancer, and it can erase the moles that are precursors of the lethal skin cancer melanoma...
...Drake received $2,000 plus travel expenses from Johnson and Johnson, Retin A's manufacturer, for moderating a January 1988 press conference, as well as honoraria for discussing the product during several television appearances. The congressional report criticizes Drake for not diclosing these fees and expenses...
Haynes, who is also associate professor of dermatology at the Medical School, said that although he first recommends sunscreen to patients with ultraviolet-related skin problems, Retin A is a possible next step...