Word: retroviruses
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...immediate obstacle to translating the results to human cells involves the way that the scientists turned back time on the mouse skin cells. They used a retrovirus vector, piggybacking the genes for the growth factors and proteins onto this infectious ferry. Retroviruses, however, like HIV, can cause infectious diseases and are not always easy to control, so before testing this approach in humans, researchers need to find other modes of transport for the critical compounds. The good news is that they need the genes to churn out their proteins for a only brief period of time, so using less virulent...
...nuclear magnetic resonance technique. “There are very few structural biologists who want to work with very large molecules,” D’Souza says. Before D’Souza’s work delineating the structure of an encapsidation signal of the murine leukemia retrovirus, researchers had only done the same for molecules of about half that size...
...knows how to solve. Perhaps this is because AIDS is a global issue that defies categorization: it has become so much a social issue that touches development, poverty, and public health, though it is still nothing but a virus. It is at its simplest a microscopic retrovirus and at its most complex an indicator of societal patterns ranging from prostitution to the unequal distribution of wealth and pharmaceuticals.What was once ignorantly considered solely a gay disease now has now been shown to be biologically nondiscriminatory with regard to gender, race, or socioeconomic status. And while this serves the benefit...
Haynes said that efforts to find a vaccine have been difficult because HIV/AIDS researchers do not yet have the tools to battle the difficulties—like rapid mutation—posed by the HIV retrovirus...
...form of tiny innovations. In Foster City, Calif., drug company Gilead has a very simple plan to tackle HIV: make the drugs easier to take. The firm gained headway two years ago when it introduced its Viread antiretroviral (HIV is a type of virus known as a retrovirus), which lasts longer than other similar medications and is more convenient for the user. In 2002 Gilead took in an incredible $226 million, almost half its annual revenue, from Viread...