Word: rheumatoid
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Dates: during 1960-1969
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Typical of rheumatoid arthritis, which may have several adverse effects upon the heart, said Silverman, is an outward turning of the fingers (with the hand viewed palm-down), along with thickening of the finger joints. In many hard-to-diagnose cases of heart disease, say the Atlanta doctors, the skilled physician's careful observation of the hands will yield valuable clues that the stethoscope and even the electrocardiograph do not disclose...
Cobb was severely handicapped by rheumatoid arthritis for the last twenty years of his life. "He continued extraordinary productivity despite an extremely painful and crippling condition," Cope said...
Equipped with bloodstream measurements as a common drug denominator, scientists can now take a more meaningful look at medicines discarded as ineffectual. A drug for relief of rheumatoid arthritis called phenylbutazone, for example, once filed away on the basis of trial doses unrefined by Brodie's findings, today has been recognized as effective for humans-even though equated doses have little result in rats...
...Aspirin. What makes lysosomes and their enzymes so important in the study and treatment of disease is their major role in cases where the inflammatory process overshoots. The overshooting has long been clear in the case of extensive burns, when the body builds too much scar tissue, and in rheumatoid arthritis, when the inflammation becomes recurrent and does permanent, crippling damage. Reports at Brook Lodge also implicated an overzealous inflammatory reaction in some kidney diseases, and made it a suspect in two still commoner diseases, diabetes and even atherosclerosis...
Last December the agency went through the motions of releasing the drug for further study. But tight restrictions were also formulated and had the effect of reaffirming the ban. DMSO can be used only externally, is limited to the few longstanding conditions, such as rheumatoid arthritis, for which there is no other satisfactory treatment. All patients must have eye examinations every three months, plus liver-function and blood tests every four weeks. Even after a doctor wins FDA approval for his research plan, he must still persuade a drug company that he is legally entitled to use DMSO...