Word: rheumatoid
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Dates: during 1990-1999
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Last week, for example, an FDA advisory panel recommended that the agency approve a new drug called Enbrel. The week before, the full FDA had given the nod to another anti-rheumatoid arthritis drug called Arava. Next month the agency will assess a promising blood-filtration device that clears the body of arthritis-promoting substances the same way kidney dialysis cleans the blood of toxins. Within a few months the FDA will also consider a new class of anti-inflammatories called COX-2 inhibitors (a.k.a. "super aspirin") that will attack arthritis pain. Says Steven Abramson, an FDA adviser and chief...
...victims arthritis simply means pain and stiffness in the joints--sometimes moderate, sometimes severe, usually responsive to treatment with one of a number of drugs. Pain can be just the beginning, though, for the more than 2 million Americans who suffer from the variant of the disease known as rheumatoid arthritis. This unfortunate minority may experience not just discomfort but also joint deformities, fatigue, nodules of tissue under the skin and inside internal organs and, in rare cases, inflammation of the membranes surrounding the heart and lungs...
Unfortunately, even the most powerful existing medications, like Methotrexate, either carry unacceptable side effects or are ineffective against rheumatoid arthritis, or both. Clinicians are understandably a bit giddy, therefore, at the news that after more than a decade of no progress, not just one but a number of new treatments are all at once streaming out of research labs...
...excitement began with a growing understanding of how rheumatoid arthritis works. Unlike its more common cousin, osteoarthritis, which causes pain in more than 20 million mostly older Americans through simple deterioration of joint cartilage, rheumatoid arthritis is a complex disease involving an immune system gone awry...
...Dutch study suggests that rheumatoid arthritis and hay fever are seldom suffered by the same person, a finding that may yield new treatments. Both conditions are thought to be autoimmune disorders mediated by two types of T cells. The type active in hay fever may help suppress the type active in rheumatoid arthritis...