Word: ridker
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...Paul Ridker at Brigham and Women's Hospital in Boston, the study tracked about 17,800 people in 26 countries. Participants included men ages 50 and older and women ages 60 and older, who had high levels of C-reactive protein (CRP) but normal cholesterol levels and no history of heart disease. Half the participants were given rosuvastatin (Crestor), and half were given a placebo daily for just under two years. The statin group reduced their CRP levels by 37%; their LDL, or bad cholesterol, levels dropped 50% to about 55 mg/dL. Among the 8,901 statin-takers, 31 suffered...
...will be made available for scientists worldwide, allowing for new discoveries in drug development and personalized disease treatment and prevention. “The hope is to get the right drug to the right patient at the right time,” said Braunwald Professor of Medicine Paul M. Ridker. “That is really the holy grail of pharmagenetics.” Ridker, who is the principal investigator of the Women’s Genome Health Study and director of the Center for Cardiovascular Disease Prevention at Brigham and Women’s, also called the study...
...PAUL RIDKER...
...risk of heart attack. The opposite is found in studies conducted with male participants, the study said. Researchers said that the study highlights the role of genetics in medicine. “Perhaps we have to think about drugs along gender lines,” said Paul M. Ridker, Harvard Medical School (HMS) Braunwald professor of medicine and a researcher of the study. Testing men and proscribing the results to women ignores “real differences between men and women,” he said. Researchers monitored nearly 40,000 women for 10 years, comparing those given low doses...
...turned out that patients who ended up with low CRP were less likely to have heart attacks or die than those whose CRP stayed high--whether or not their LDL levels went down. Showing that CRP reduction is at least as important as cholesterol reduction, says Dr. Paul Ridker, lead author of the report, is a "home...