Word: rifampin
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Until recently, the outlook for patients with drug-resistant TB could not have been gloomier. The last major anti-TB drug, rifampin, was approved more than a quarter-century ago. In the interim, the TB bacillus has managed to develop resistance to the cocktail of drugs physicians have long used to treat it, including that old standby streptomycin. New drugs, with different mechanisms of action, would be a great help, particularly if they shortened the present six months' time required for treatment. The linezolid family, for example, appears to hold some promise, as does a compound the Seattle-based PathoGenesis...
...been treated effectively with a sulfone drug called dapsone. Recently, however, doctors have noticed an alarming increase in the number of cases resistant to dapsone. The most promising therapy would use several drugs in combination so that patients would not develop a resistance to any one medication. The antibiotic rifampin, a leading antituberculosis drug, has proved effective, healing leprous skin lesions four times as fast as dapsone. Unfortunately, it can cause flulike side effects, and a year's supply may cost $600. The annual bill for dapsone is about...
...surgery he again developed pneumonia, and analysis of the guilty bacteria proved them to be similar to those identified in Durban. They were astonishingly resistant to penicillin and also to many newer antibiotics. In the boy's case, the hardy new pneumococci finally succumbed to combined doses of rifampin and fusidic acid, but doctors noted that he was already recovering when the drugs were administered...
...been developed by U.S. researchers, tested at the Public Health Service Hospital in Carville, and just released for use in Hawaii. The best-known and most widely used is dapsone (DDS). For those who also had tuberculosis, isoniazid was used. Still newer drugs include the potent antibiotic rifampin, and even thalidomide, which is administered to treat complications, but not for women of childbearing age. Collectively, these are indeed wonder drugs: when used promptly to treat newly discovered cases, says Koch, they can usually make the patient noncontagious within a week...
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