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...rewarding experiences trigger the release of the neurotransmitter dopamine - the brain's "do it again" signal. Over time, addicts' brains become narrowly focused on drug-related pleasures and hypersensitive to cues associated with them, such as seeing an old drinking pal. Hanging out with that friend would prompt a rise in dopamine levels in the brain's reward system. Researchers think that's where baclofen cuts in: by binding to the GABA-B receptor in the brain, it modulates this system and prevents the release of dopamine in response to cues. That appears to short-circuit cravings...

Author: /time Magazine | Title: Treating Alcohol Addiction: A Pill Instead of Abstinence? | 7/29/2009 | See Source »

...work outside the home, and a recent high court decision decriminalized homosexuality. Clubs, bars, and restaurants cater to both Western tastes and a growing middle-class with ever more disposable income. But isn’t it odd that even recent cinematic history still records India’s rise from slums-to-riches as possible only with the Western helping hand—an adaptation of America’s Who Wants to be a Millionaire...

Author: By Ashin D. Shah | Title: The Allure of Western Culture | 7/29/2009 | See Source »

...native varietals were never replanted in favor of others more productive or disease-resistant. Since then, more still have been abandoned as French winemakers, like those the world over, began growing the likes of chardonnay and merlot to offer standardized global bouquets. Today, though, a few are seeking to rise above the glut, by bringing back the forgotten varietals of France's viticultural past - some of which have survived in institutional collections, others in obscure patches of remote vineyards...

Author: /time Magazine | Title: French Wine's Growth Potential | 7/29/2009 | See Source »

...with the air, water, plants, other animals. But in the past two centuries, beginning with the Industrial Revolution, people have been steadily removed from the natural world, our lives regulated not by the sun or moon but instead by the factory clock. Recently it's gotten worse, with the rise of the Internet and other technologies, like iPhones and BlackBerrys, that dominate our lives, pushing us even further from any appreciation of our natural surroundings. (See the best iPhone applications...

Author: /time Magazine | Title: 'Eco-Therapy' for Environmental Depression | 7/28/2009 | See Source »

...dialogue. But the North has always wanted to sideline the South Korean government in Seoul, with whom it has never signed a peace treaty, as well as the Japanese government, which regime founder Kim Il Sung fought to dislodge as occupier of the Korean peninsula. (See pictures of the rise of Kim Jong...

Author: /time Magazine | Title: Is Kim Jong Il Really Ready to Talk? | 7/28/2009 | See Source »

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