Word: ritonavir
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...years later. "The [pharmaceutical company] said they didn't have the right dosage for children," the girls' foster mother recalls. "They told us to hold out. But by the time she got accepted, it was too late [for Tanya's sister]." In February, Tanya started combination therapy with ritonavir and has since added seven pounds to her 75-lb. frame. The popular sixth-grader now feels well enough to have sleepovers at a friend's house and go on school field trips...
They got some incentive two weeks ago, when the FDA approved for the first time the use of two protease inhibitors for children--Agouron's nelfinavir and Abbott's ritonavir. But parents and pediatricians complain that they still don't have enough information about how to use them. Nelfinavir, in particular, "went through the approval process very rapidly," says Dr. Mark Kline, associate professor of pediatrics at Baylor College of Medicine in Houston. "There are some basic pieces of information about nelfinavir that we don't have--like how often to give the drug or in what dose...
News from Abbott Laboratories that an experimental drug called ritonavir cut in half the death rate for a group of patients suffering from advanced AIDS--at least during the seven-month period of the study...
...Both ritonavir and indinavir belong to a promising new class of drugs called protease inhibitors, which block production of a key enzyme, protease, that the virus needs to replicate itself. It was only last December that the U.S. Food and Drug Administration approved the first protease inhibitor, Hoffmann-La Roche's saquinavir. Ritonavir and indinavir could get the FDA go-ahead--and reach doctor's offices--as early as this summer. "The data are as good as anything I've seen," says Dr. Anthony Fauci, a leading AIDS expert at the National Institutes of Health...
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