Word: rna
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Dates: during 1970-1979
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...fairly non-technical fashion. Monod hypothesizes how the nucleic acids might have originated as the information carrier molecule, suggests that the genetic code may have come into being purely randomly, and even suggests a mechanism for DNA-protein specificity of translation that may have originated without an RNA intermediate...
Clear Implication. To find out if those orders were being given, the scientists used another laboratory trick. Before incubation was completed, they had radioactively tagged the cells' messenger RNA (the single-stranded molecule that carries genetic instructions from one part of the cell to another) so they could later identify it. Then they mixed these radioactive strands with complementary strands of genetic material from viruses carrying the crucial gene, hoping that they would combine; pairing off would take place only if the cellular RNA now had the same genetic structure...
...their great satisfaction, the experimenters found that such hybridization of the viral and RNA strands had occurred. In contrast, when the researchers tested RNA from cells that had not been exposed to the viruses, hybridization virtually ceased. The implication was clear: the cells were indeed ordering up the essential enzyme. Furthermore, the scientists not only found the enzyme and confirmed that it was chemically active but also determined that the cells passed on their enzyme-making ability when they reproduced themselves...
...animals. Then "as tolerance [to marijuana] developed, hyperactivity became prevalent after day seven." As the tests continued, the frenzied activity of the rats began to culminate in seizures, convulsions and, in some cases, death. Autopsies revealed that the exposed rats had suffered a loss of brain protein and RNA, both of which play an important role in brain function. These changes occurred from 28 to 91 days after the first of the daily doses of marijuana...
Last week, after winning a U.S. Public Health Service award for co-authoring a paper entitled "The Inhibiting of DNA and RNA Synthesis by Dau-norubicin and Adriamycin in 1-1210 Mouse Leukemia," Meriwether moved to a new job at the Thorndike Memorial Laboratory in Boston. "I haven't talked to my new employer," he says. "He may not dig track." A more important question is whether Meriwether digs competing in the 1972 Olympics in Munich. "First things come first," he says. "My family and my work. But whether I do or don't compete...