Word: rna
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...Souza’s approach to HIV research is unique because she uses structural biology. Her research focuses on the first step of the viral life cycle of HIV—the process of reverse transcription—in which the virus changes its genome from RNA...
Currently, most anti-HIV drugs target individual proteins, and are given in combination as a cocktail. However, according to D’Souza, HIV is mutating and building up resistance to the cocktail. By studying the RNA-protein complex, which is crucial to the virus’ survival, D’Souza aims to sophisticate the current approach to AIDS treatment...
...It’s really at the cutting edge of structural biology of RNA,” she says...
...next three to four years, D’Souza says she should be close to solving the structure of the RNA-protein complex, which is, according to her, “probably the most difficult part...
...Harvard alum Roger D. Kornberg ’67 received the Nobel Prize last week for uncovering the crystal structure of the protein necessary to make DNA more than just a blueprint. Kornberg, who is currently a professor at Stanford University, presented a frame-by-frame view of RNA polymerase interacting with DNA——a conversion that leads to the construction of proteins necessary for life. Kornberg’s discovery, published in the journal Science in 2001, showed in atomic detail the chemical construction of RNA polymerase, a protein complex made of 12 long chains...