Word: rogosin
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
Cautious optimism also pervades the Rogosin Institute in New York City, where Dr. Bruce Gordon, an expert on treating high cholesterol, became intrigued with the fact that cholesterol and blood lipids (fats) in people with severe illness or injury tend to drop to abnormally low levels. This makes them more vulnerable to sepsis, he reasoned, because one of the lipids' functions is to bind to and neutralize endotoxins. His unorthodox solution (especially for someone known for fighting high cholesterol): try to raise lipid levels in sepsis victims...
Working with a lipid emulsion derived by Rogosin researchers from soybeans, Dr. Joseph Parrillo, a leading authority on sepsis at Chicago's Rush medical center, infected 19 pigs with bacteria containing endotoxin, then infused the Rogosin emulsion into eight of them. The results were striking. All 11 of the untreated pigs died, while seven of the treated animals survived. Says Parrillo: "It's kind of convincing...
...levels. Even many laboratories have been unable to give consistently accurate counts of HDL. Yet that figure may be the most vital statistic of all in evaluating cardiovascular health in otherwise moderate- or low-risk individuals. Says Dr. Bruce Gordon, associate professor of medicine at Manhattan's Rogosin Institute: "There are a sizable number of people who would be inappropriately treated unless their HDL levels were taken into account...
...hopeful development is that scientists have learned how to derive synthetic HDL particles from natural HDL made in the body. At the Rogosin Institute, researchers are injecting this compound into rabbits to see if raising HDL protects them against atherosclerosis. Should such experiments succeed, it is conceivable that synthetic HDL could one day become an effective treatment for heart patients. Rogosin's Gordon notes, however, that this research "is still years away from clinical application...
Many questions about the new procedure remain. Is one weekly session better than two? How long should patients be treated? The severest genetic cases, like Yuko's, would probably require lifelong treatment, says Rogosin's Dr. Bruce Gordon, but with most patients "the goal is to give a course of therapy from six months to two years, produce a beneficial effect and then hopefully keep the patient stable with diet and drugs...