Word: rosenberger
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...event's chief organizer, PCC counselor Laura A. Rosenberg '92, also said that she was happy with the lecture's results...
Widely covered by the press, the procedure prompted dozens of phone calls to the NCI from patients desperately seeking a cure. Rosenberg stresses, however, that his work is highly experimental. The treatment puts a new twist on classic vaccine strategy. "When you think of a vaccine, it's usually to prevent a disease," he explains. "Here we're actually treating an advanced cancer...
...Rosenberg and his team have permission from the National Institutes of Health and the Food and Drug Administration to treat 15 people with TNF-gene- altered cells, including patients with advanced kidney or colon cancer. Another 15 individuals with the same diseases may receive injections of tumor cells that have been genetically altered to produce interleukin-2 -- a protein that stimulates tumor-fighting lymphocytes -- instead of TNF. All the patients have failed to respond to standard therapy...
...promising as the approach sounds, some researchers are disturbed by Rosenberg's announcement. They argue that a human trial is premature, given the limited results of this treatment in animals. While Rosenberg's method has been shown to prevent the formation of new tumors in healthy mice, there is no published evidence that it can counteract existing cancers. Rosenberg, however, maintains that he has ongoing animal experiments to support his work and that he submitted extensive unpublished research data before obtaining permission to proceed: "This was reviewed for eight months by about 50 scientists on at least five committees...
...Rosenberg has also been criticized for inflating patients' hopes by publicizing his experiment before there are any results to report. "It's a very high-profile research activity that Steve Rosenberg is running," Dr. Philip Leder of Harvard University School of Medicine told the New York Times. "He didn't come to you after the experiment was successful. He came at the beginning, because it might be quite uninteresting when it's all finished." Given all the attention and elevated hopes, Rosenberg should reveal his results -- even if they are uninteresting -- with the same alacrity he shows in announcing...