Word: roth
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Dates: during 1990-1999
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...earliest to do so was Mathews-Roth,who legitimized beta carotene as a viable medicaldrug in the mid-1970s. Then working onprotoporphyria, an obscure disease which rendersits sufferers highly sensitive to light,Mathews-Roth stumbled across the organic moleculeas a treatment...
...Mathews-Roth found that huge doses of betacarotene--up to 180 milligrams a day--can preventthe protoporphyria molecule from reacting withoxygen, and thus cures protoporphyria in all butthe most severe cases...
...vast majority of people will be able to goout in the sun," says Mathews-Roth, whosetreatment won approval in 1975 from the Food andDrug Administration for her discovery...
Both Hennekens and Mathews-Roth admit that herprotoporphyria research was an important step inthe evolution of the Physicians' Health Study. Bydemonstrating that huge doses of beta carotene hadno adverse effects on the subjects (except for therather unfortunate consequence of turning theirskin yellowish-orange), she was able to sellHennekens on the safety of the drug in alarge-scale clinical trial...
...this sort of thing, you'll neverknow...whether it's because the stuff doesn'twork, or whether the stuff wasn't given for longenough and high enough doses," says Mathews-Roth...