Word: sabeti
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Dates: during 2000-2009
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Pardis C. Sabeti, an assistant professor of organismic and evolutionary biology who received a New Innovator Award, said she will use the funds to further her research into the Lassa fever which she describes as “the most deadly disease known...
...when clearly that isn’t true,” Newton said. “The goal was to educate people about race and genetics, and to get people talking about sensitive issues, which is always difficult,” she added. Professor Scott V. Edwards and Pardis Sabeti from the Department of Organismic and Evolutionary Biology lent the scientific perspective, explaining the mechanics of this sort of gene mapping as well as the background behind the Genographic Project, which Edwards helps advise. In addition to analyzing the genetic material of the general public, the organization collects samples from...
...genes of the parasite in Africa, Asia, and South America. This genetic variation gives Plasmodium falciparum the ability to overcome vaccines and other treatments for malaria, allowing the disease to continue spreading. “It’s very rapidly evolving,” said Pardis C. Sabeti, a Broad Institute researcher who contributed to the study and whose previous work has focused on natural selection in humans. Sabeti, like Wirth, was reached in Senegal—a country that ranks 11th worldwide in malaria prevalence, according to information from the United Nations University. In 2000, malaria affected...
...fruitful this approach to studying disease will be, adding that he is open-minded and optimistic. Using the same approach, he said, researchers have identified a gene for a common form of blindness. The HapMap also has implications for the study of evolution and natural selection. Pardis C. Sabeti, a student at HMS and a postdoctoral fellow at the Broad Institute, looked for recent, common mutations in the genome. These genes are too young to have risen to their current frequency by chance alone, and so are likely candidates to be the products of recent natural selection. Sabeti...
...Sabeti and her co-authors gathered genetic samples from men in Africa, where 90 percent of the world’s malarial deaths occur, as well as from subjects in Europe and East Asia...