Word: sabeti
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...genes of the parasite in Africa, Asia, and South America. This genetic variation gives Plasmodium falciparum the ability to overcome vaccines and other treatments for malaria, allowing the disease to continue spreading. “It’s very rapidly evolving,” said Pardis C. Sabeti, a Broad Institute researcher who contributed to the study and whose previous work has focused on natural selection in humans. Sabeti, like Wirth, was reached in Senegal—a country that ranks 11th worldwide in malaria prevalence, according to information from the United Nations University. In 2000, malaria affected...
...fruitful this approach to studying disease will be, adding that he is open-minded and optimistic. Using the same approach, he said, researchers have identified a gene for a common form of blindness. The HapMap also has implications for the study of evolution and natural selection. Pardis C. Sabeti, a student at HMS and a postdoctoral fellow at the Broad Institute, looked for recent, common mutations in the genome. These genes are too young to have risen to their current frequency by chance alone, and so are likely candidates to be the products of recent natural selection. Sabeti...
...Sabeti and her co-authors gathered genetic samples from men in Africa, where 90 percent of the world’s malarial deaths occur, as well as from subjects in Europe and East Asia...
This advance holds significant implications for the study of human disease and its treatment, according to Pardis C. Sabeti, the medical student who led the study...
...Sabeti and her team have already used the LRH test to identify the positive selection of two genes associated with resistance to malaria, a life-threatening parasitic disease transmitted by mosquitoes...