Word: salk
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Dates: during 1990-1999
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Gene therapy, simply defined, is the placement of beneficial genes into the cells of patients. By introducing the gene and consequently the protein it produces, says Inder Verma, a professor at the Salk Institute in La Jolla, Calif., "you either eliminate the defect, ameliorate the defect, slow down the progression of the disease or in some way interfere with the disease...
...field agree that the adenovirus and retrovirus vectors are imperfect, to say the least. In addition to having immunological side effects, both lack the carrying capacity to accommodate the larger, more complex genes that would be useful in therapy. "There are only three problems in gene therapy," says Salk's Verma, "delivery, delivery and delivery. It isn't going to be a problem to make gene therapy work--if we have an appropriate set of tools to deliver the genes...
...other new vector is being fashioned by Salk's Verma. "What we want," he says, "is a virus that is easy to make, that delivers genes at very high efficiency, that can infect a nondividing cell and that enables its therapeutic gene to become part and parcel of the chromosome...
...Polio vaccine 1955, by Jonas Salk, approved...
...Salk said the Afro-American studies department is especially pleased because her department's large new space in the Barker Center--which features a special library--will finally allow it to operate more closely with the DuBois Institute...