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That's a far cry from the climate in most of the U.S., where - despite the recent election of Annise Parker, a gay woman, as mayor of Houston, America's fourth largest city - honesty can still end a gay politician's career. Openly gay politicians such as San Francisco supervisor Harvey Milk began winning seats in U.S. cities with large gay populations in the 1970s. Progress has since slowed, says David Rayside, a professor of political science at the University of Toronto. He believes that the relative strength of incumbency in the U.S. creates a barrier to the corridors...
...suggests that HIV therapy is only going to become trickier and more expensive to implement as drug resistance spreads. While the implications for this trend will be felt most acutely in sub-Saharan Africa and parts of Asia, Kahn says he also has concerns for his home city of San Francisco. "California is broke, and the state is invading city finances to help itself out. I look at our model and what it predicts for San Francisco over the next few years in terms of antiretroviral resistance, and I do become concerned that funding is on the chopping block...
...Kahn, a professor of medicine at the University of California, San Francisco, and a contributor to the Science study, says test and treat should not be confused with WHO's goal of universal access to antiretroviral drugs, which he says is a worthy one. But because the treatment for drug-resistant HIV strains is expensive - it requires a constantly changing cocktail of new, pricey drugs - and because adherence to such a complicated drug regimen can be difficult for patients, Kahn believes WHO and other institutions should begin planning for the time that HIV drug resistance begins in earnest, particularly...
Researchers at Harvard and the University of California, San Diego have discovered that mutations in the HIV virus work together to induce drug resistance—a finding that may offer new leads in HIV drug research and therapy...
After the Harvard researchers found possible combinations of mutation site interactions, scientists at UC San Diego digitally simulated the effects of each mutation on the protein-drug binding energies...