Word: sandoz
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Dates: during 1980-1989
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...drug companies encourage skepticism among doctors and pharmacists about the quality of some generic products. Sandoz last year ran an ad in the American Druggist magazine for the tranquilizer Mellaril. It showed an elderly woman with an alarmed look on her face. In her hand was a vial that apparently contained a generic imitation of Mellaril. The text implied that a switch to a generic version of Mellaril could cause increased side effects, including symptoms similar to those of Parkinson's disease. The FDA said that the claims in the ad were false and ordered Sandoz to withdraw...
...dismal present of losing jobs, families and homes. The initial round of news coverage, portraying Tent City as a virtual human metaphor for the effects of the recession, prompted a mammoth, warmhearted response from the Houston community. Everything from fresh fruit to live poultry began arriving. Says Howard Sandoz, a railroad inspector who brought over 12 lbs. of steak: "I saw the tent people on TV and thought about all the food I had. I'm just doing my part." Houston-area companies contributed tents, rolls of plastic, Coleman stoves, water tanks and portable toilets. Stacks of donated firewood...
...thanks to an important new drug called cyclosporine, the heart transplant may become the more nearly routine operation doctors once envisioned. Developed by the Swiss firm Sandoz Ltd., cyclosporine is a natural fungal compound that somehow blocks the production of those white cells that cause rejection but not those that fight infection. Says Dr. Barry Kahan, head of the organ-transplant division of the University of Texas Medical School at Houston and a colleague of Cooley's: "This is the secret ingredient, the thing that unlocks the door to transplants...
...experimental use in the U.S. since 1979, cyclosporine, says Sandoz, has dramatically increased survival rates for kidney transplants, from a range of 45% to 55% to a range of 80% to 90%, and for liver transplants from 30% to 70%. The first heart transplant using cyclosporine was performed in December 1980 by a Stanford University team, including Oyer and headed by Dr. Norman Shumway, who had pioneered the first heart transplant in the U.S. twelve years earlier. The team has now done 36 transplants using cyclosporine, and although Oyer cautions, "It's too early to tell," the preliminary...
Cyclosporine is not a panacea for transplant problems. It is expensive to make and produces some ominous side effects: it is toxic to the kidneys, and there is some evidence that it is associated with lymphatic tumors. But both conditions appear to be linked to higher dosages. Sandoz is submitting cyclosporine to the Food and Drug Administration for approval this fall...