Word: sanofi
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...newest vaccine, called FluLaval, and distributed by GlaxoSmith Kline, is similar to the four other shots currently available (Fluzone, from Sanofi Pasteur and Connaught Laboratories; Fluvirin, from Novartis and Evans; FluMist , from MedImmune; and Fluarix, also from GlaxoSmith Kline). Like them, it is made by incubating strains of the influenza virus in chicken eggs. What it does contribute, however, are more doses of vaccine - a fact that federal health officials are especially keen on stressing, imm, since an unexpected shutdown of a major vaccine manufacturer in 2004 left the U.S. with a shortage of shots. "We are thrilled with...
...study being published in Thursday?s New England Journal of Medicine provides disappointing news on the avian flu front. The good news is that the study of 451 healthy adults shows that a vaccine manufactured by Sanofi Aventis using current standard techniques is safe. The bad news is that the inoculation will most likely be effective in humans only at the highest doses. Furthermore, the results show that the vaccine - as it is currently constituted - would take two and perhaps three injections to achieve good protection. That is a problem, since the U.S.?s already modest stockpile of material...
...Then there is the matter of having the right strains of virus in the vaccine should a human pandemic ever occur. The virus used to make the Sanofi Aventis vaccine came from a Vietnamese patient who was infected with H5N1 in 2004. The viruses from that sample are part of a group that scientists call clade 1. But the viruses that have recently spread so rapidly among birds from Asia to Europe and Africa are part of a new group called clade 2. Preliminary evidence suggests that there?s not a lot of cross-reactivity between the two clades. That...
When scientists at Sanofi-Aventis took on the challenge of developing a weight-loss drug, they chose an unusual approach. Instead of studying ways to curb the body's natural desire to eat, they decided to home in on the very biological circuits that activate hunger. Even more unorthodox was the craving phenomenon they decided to analyze: the marijuana munchies. If marijuana can trigger the appetite, then perhaps that system could be coaxed into switching...
...three months. Chiron, one of the world's leading manufacturers of the egg-dependent flu vaccine, is testing its first cell-culture technique, which it plans to apply to seasonal and pandemic flu vaccines. The Department of Health and Human Services last spring awarded a $97 million contract to Sanofi-Aventis, a Paris-based drug company, to develop avian-flu vaccines using human cells. The company is preparing a 20,000-liter bioreactor tank in the U.S. to brew test cultures. Jaap Goudsmit, chief scientific officer for Netherlands-based Crucell, which supplies cell-culture technology to Sanofi-Aventis, expects...