Word: saponins
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Dates: during 1971-1971
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Working in cooperation with other researchers, Wolf and Nalbandian discovered chemicals that would react to hemoglobin S and other less harmful sickling substances, making a quick screening test possible. A small blood sample is dropped into a tube containing a solution of potassium phosphate, sodium dithionite and saponin. Clouding of the solution is a danger signal but does not specifically identify hemoglobin S. If the first round arouses suspicion, a second test, also based on Murayama's work, is performed immediately. Urea, a natural waste substance produced by the normal liver, breaks some molecular bonds in abnormal hemoglobin. When...
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