Word: saquinavir
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Dates: during 1990-1999
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Then the FDA approved a new medication called saquinavir. One of the so-called protease inhibitors, it attacks the virus at a previously untargeted step in its reproductive process. Several similar drugs have since followed. The agency also approved a medication called 3TC. Although it works much like AZT, the two act as a chemical tag team: after HIV becomes resistant to AZT, it is still vulnerable to attack by 3TC. If it then develops resistance to 3TC, it suddenly loses the ability to fend off AZT. Multiple-drug therapy had finally become possible...
...indinavir belong to a promising new class of drugs called protease inhibitors, which block production of a key enzyme, protease, that the virus needs to replicate itself. It was only last December that the U.S. Food and Drug Administration approved the first protease inhibitor, Hoffmann-La Roche's saquinavir. Ritonavir and indinavir could get the FDA go-ahead--and reach doctor's offices--as early as this summer. "The data are as good as anything I've seen," says Dr. Anthony Fauci, a leading AIDS expert at the National Institutes of Health...
...well be that the more sophisticated and effective HIV treatments become, the fewer people will have access to them. This grim new calculus is painfully apparent to Patrick Roll, 41, of Boston, whose T-cell count has dropped below 50 and who takes nine capsules of the protease inhibitor saquinavir each day. Considering that he first tested positive in 1983, he is in remarkably good health. "I'm from a socioeconomic group that had careers," he notes. "We've been able to keep our insurance or afford to take it on ourselves." Not everyone is as fortunate as Roll...
...advisory panel recommended the full approval of three new anti-AIDS drugs. One drug, called saquinavir, is the first in a new generation of potent AIDS fighters known as protease inhibitors, which attack the virus in the late stages of its reproduction...
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