Word: sarcoma
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Dates: during 1970-1979
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Michael Flanigan of West Philadelphia, Pa. In 1963, when he was six, doctors gave him only six months to live because of what they considered an incurable case of Ewing's sarcoma, a bone cancer. Several times his parents carried Michael to the Neumann Shrine at Philadelphia's Church of St. Peter the Apostle, where the bishop's body is on display behind glass in the altar. Six months after the diagnosis was made, there were no signs of the disease...
...clinical research has been most successful recently with a program for the treatment of bone cancer, osteogenic sarcoma, by chemotherapy, or the administration of chemicals. The field that Frei extols--medical oncology--is the study of tumors, and it is neither clinical nor pure research by his definition. Rather, Frei explains, it is a field only now "coming to fruition," involving scientist from almost all disciplines, and concerned especially with the effects of radiation therapy and chemotherapy on malignancies. In the Farber Center, Frei boasts, "No man can be an island; optimal evaluation and treatment for cancer involves the multiple...
...various types of cancer that afflict children, few are more fearsome than osteogenic sarcoma, a tumor that originates in the bone and spreads rapidly. By the time doctors can tell that the pain in a youngster's arm or leg is the product of such a tumor, the odds are strong that microscopic clusters of malignant cells have already reached the lungs. Removing the primary tumor by amputation saves the patient from early death. But in 80% of the 150 cases of this cancer reported among patients under age 15 in the U.S. annually, a secondary tumor appears...
Until recently, all doctors could do in most of these cases was to try to slow the cancer's fatal course with chemotherapy. Now a new-though risky -way of using an old drug called methotrexate is improving the outlook for victims of osteogenic sarcoma...
...doctors were frustrated for years by the fact that standard doses of the highly toxic drug had no effect on osteogenic sarcoma cells, yet left patients suffering various unpleasant and even dangerous side effects-anemia, impaired liver and kidney function, mouth ulcers, nausea and hair loss...