Word: saxitoxin
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Dates: during 2000-2009
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Kohane said the “key” ingredient was saxitoxin, a known antibiotic, that produced nerve blocks lasting up to two days...
...When saxitoxin was combined with the steroid dexamethasone, the nerve block extended for seven days, said Epstein-Barash...
Unlike conventional anesthetics, which often cause toxicity to surrounding tissues, impeding the development of slow-release anesthetic systems, the sustained release formulation containing saxitoxin resulted in very high local concentration—“the rat’s leg fell asleep”, said Kohane—but surrounding tissue did not sustain damage...