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That grim situation could have been avoided, researchers say. An estimated 12 million American women are routinely prescribed statins, which carry a risk of serious side effects. Yet there is little evidence that they prevent heart disease in women. In past research, statin therapy has been shown to prolong the lives of people with heart disease. It has also been shown to stave off the onset of heart disease in healthy at-risk adults. But researchers who have broken out and analyzed the data on healthy female patients in these trials found that the lifesaving benefit, which extends...
...researchers say the field has not taken the next step: tailoring treatments according to gender-specific data. In many cases, notably with statins, they say the data are missing or have not been properly analyzed...
Other researchers say that evidence is muddy. The reduction in cardiovascular events sounds impressive until you take a closer look. Men taking Crestor had a lower risk of hard events, including fatal and nonfatal heart attack and stroke. But the only statistically significant benefits for women treated with Crestor involved less extreme end points, like hospitalization for unstable chest pain and arterial revascularization (a category of procedures that includes major surgery). To prevent one event, 36 women would need to take the statin for five years - a modest result, critics say...
Meanwhile, women on Crestor were more likely to develop diabetes compared with those getting a placebo - a result not seen in men. And because the trial lasted only 1.9 years on average, researchers say the full magnitude of the side effects may not have been captured...
...last week's alert that the Oklahoma catastrophe-which "patriots" suspect involved three bombs, not one-was a government plot to enable President Clinton to proclaim martial law and divert attention from forthcoming hearings on the Whitewater financial scandal. Indeed, Miller's attitude toward the Oklahoma City culprits -- "I say hang 'em" -- sounded much like the President...