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...Nora Volkow, director of the National Institute on Drug Abuse, takes a more sober view of the findings, pointing out that 18 of the 26 studies in Noble's review failed to mention addiction. The review authors say they assumed the omissions meant that those studies did not find any cases of addiction, but Volkow says it could mean that they simply didn't look for it. (See pictures from an X-ray studio...
Still, Volkow does not deny that age and prior addiction are key risk factors for drug problems; addiction is primarily a disorder of youth. Based on this review and other research involving middle-aged or older people screened for pre-existing drug problems, Volkow says, "Under those conditions, you can say that the risk [of addiction] is less than 3% [in people with no history of drug abuse...
...identify exactly what went wrong in all of the cases. Was it the high-prescribed dose alone, or were there other risk factors like illness, escalation of pain or undiagnosed addiction? While Von Korff and Volkow agree that prescription dose is a major contributor to overdose risk, they say better studies are needed to determine the precise causes and consequences. "One would hope that for a treatment regimen that millions of people are using, we'd have large, long-term, well-designed randomized controlled trials, and we don't," says Von Korff. (See "The Year in Health 2009: From...
What might have happened back in the Pliocene, say Fedorov and his colleagues, is that an initial bout of global warming led to severer hurricanes - a distinct possibility supported by recent research published in Science and Nature Geoscience - and severer hurricanes led to more warming. Although most of us think about hurricanes in terms of their impact on the land, they also wreak havoc on the sea, churning the water like giant mixers and forcing warm surface waters deeper. When that occurs in the central Pacific, "the ocean responds by sending that water to the East," where it rises again...
...working on the book proposal I had all these books about poison stacked around me, and he goes, "You know, if I die of poison, everyone is going to know you did it." Well, thanks a lot, right? (Laughs.) Even now when I go to the office people will say, "Be nice...