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...genetic screens included one set of 101 gene changes that have been linked to heart disease as well as to factors that can contribute to heart disease, such as high blood pressure, diabetes and high cholesterol. The second genetic screen was a leaner library of 12 genetic changes for which published studies have found a definitive link to heart disease only...
...established by a landmark study that began in 1948 (and continues today), which identified seven major predictors of heart disease - older age, diabetes, smoking, high blood pressure, high total cholesterol, low HDL cholesterol and a BMI in the overweight or obese range. The Reynolds score is a more recent screen that uses the Framingham risk factors as a base and adds another, inflammation, which in recent studies has been linked to an increased risk of heart disease. (See the 50 best inventions...
Among the more than 19,000 women followed in the study, published Tuesday, Feb. 16, in the Journal of the American Medical Assocation, those deemed by the genetic screen to be in the lowest risk group had a 3% risk of developing heart disease, while those in the highest risk group had a 3.7% risk - just barely significant and, by Paynter's admission, not a large difference at all. "Adding the risk scores really didn't add anything," she says. (See the top 10 scientific discoveries...
Apart from Kutcher, Jamie Foxx, Bradley Cooper, and Queen Latifah all deliver strong performances, especially considering the extraordinarily limited amount of screen time they have to work with. The rest of the A-list ensemble, however, are somewhat poorly chosen, seemingly cast in the movie only for name recognition...
...festival would be fun and not too heavy. Regardless of whether or not the mood of the festival is light, attendees can be sure that their stomachs will be heavy with food after the screenings—a fitting complement to the fare that they saw on the big screen...