Word: serotonin
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Dates: during 1990-1999
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...alarmed at the monster that Johns Hopkins neuroscientist Solomon Snyder and I created when we discovered the simple binding assay for drug receptors 25 years ago. Prozac and other antidepressant serotonin-receptor-active compounds may also cause cardiovascular problems in some susceptible people after long-term use, which has become common practice despite the lack of safety studies...
...didn't know what serotonin was until I found out I didn't have enough of it. I hadn't been sleeping well--for years, it seemed--and I went to my general practitioner for help. I described a pattern of waking up two or three times every night. "That's textbook," my doctor said. "Textbook what?" I asked. He stunned me by answering, "Textbook depression...
...later feeling terrific. The drug had worked immediately--no waiting period--and it continued to work night after night. What's more, my days were different. Brighter. Smoother. My famously spiky temper tapered off. Like a headache one doesn't know he has until it's gone away, my serotonin deficiency revealed itself only once a drug had filled...
...MADELEINE NASH, our senior science correspondent, reported on the brain's chemical pathways for our cover story on serotonin, a complex substance that influences a wide range of emotion and behavior. She knows the routes well, having written a cover story on another brain chemical, dopamine, and its role in addiction. Last week she looked at the natural antidepressant St. John's wort. Nash brought her usual clear-sightedness to the murky workings of serotonin and the trial-and-error science that brought forth beneficial--and potentially deadly--serotonin-enhancing drugs such as fen/phen. Nash's work...
...HOFFMAN, our new deputy art director, was wary of designing a cover package on something that isn't very visible. "I thought, Here I get to profile a molecule," she says. "How do you make juice out of that?" She did, by gamely examining every aspect and angle of serotonin to produce an informative and visually arresting package. Previously a design director at the Boston Globe, Hoffman doesn't miss the daily deadlines. "Now I can dig more deeply," she says, although at TIME that can mean digging deep into the night. "Cynthia gets to the core of every story...