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...These days Beddoe, 33, spends much of her time at home in Melbourne reading up on psychiatry while working on a book about her ordeal. She's certain that what made her sick were side effects of the most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs). A pharmaceutical phenomenon that began with fluoxetine (Prozac) in the late 1980s, the SSRIs rode a wave of gushing publicity to usurp the older antidepressants, the tricyclics, and reap a fortune for their makers: worldwide sales now exceed $20 billion a year. But the honeymoon is over. Even doctors...

Author: /time Magazine | Title: Bitter Pills | 11/14/2005 | See Source »

...part of Battaglia's study, he collected saliva samples from his 49 subjects and analyzed their DNA, looking for something that might further explain his results. The shy children, he found, had one or two shorter copies of a gene that codes for the flow of the brain chemical serotonin, a neurotransmitter that plays a role in anxiety, depression and other mood states. Battaglia's lab is not the only one to have linked this gene to shyness, and while nobody pretends it's the entire answer, most researchers believe it at least plays a role. "People who carry...

Author: /time Magazine | Title: Secrets of the Shy | 3/28/2005 | See Source »

...with an internet connection in every seat Take a Hike Destinations to restore your sense of wonder Adding to the concerns about antidepressant use, a Dutch report in the Archives of Internal Medicine highlighted another problem with the pills: abnormal bleeding. Patients taking drugs that strongly inhibit reuptake of serotonin - a neurotransmitter that aids both mood and blood clotting - were at least twice as likely to be hospitalized for bleeding in the brain, uterus and other sites than patients taking weaker drugs. So-called SSRIs, including Prozac and Paxil, were among the strongest drugs. The risk is small, however...

Author: /time Magazine | Title: New Prozac Blues | 1/16/2005 | See Source »

...Adding to the concerns about antidepressant use, a Dutch report in the Archives of Internal Medicine highlighted another problem with the pills: abnormal bleeding. Patients taking drugs that strongly inhibit reuptake of serotonin-a neurotransmitter that aids both mood and blood clotting-were at least twice as likely to be hospitalized for bleeding in the brain, uterus and other sites than patients taking weaker drugs. So-called SSRIs, including Prozac and Paxil, were among the strongest drugs. The risk is small, however, and most serious for patients already at elevated risk for bleeding...

Author: /time Magazine | Title: Your Health | 1/16/2005 | See Source »

Adding to the concerns about antidepressant use, a Dutch report in the Archives of Internal Medicine highlighted another problem with the pills: abnormal bleeding. Patients taking drugs that strongly inhibit reuptake of serotonin--a neurotransmitter that aids both mood and blood clotting--were at least twice as likely to be hospitalized for bleeding in the brain, uterus and other sites than patients taking weaker drugs. So-called SSRIs, including Prozac and Paxil, were among the strongest drugs. The risk is small, however, and most serious for patients already at elevated risk for bleeding...

Author: /time Magazine | Title: New Prozac Blues | 12/17/2004 | See Source »

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