Word: shaw
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...There are [currently] more than 10 potentially valid therapeutic agents, but each has to be optimized in dosage, at what stage of infection it is first given, and whether it is effective combined with other drugs," Shaw said. "Right now, it can take years to test just two or three drugs whereas [we believe] one can explore the potential in just one or two months...
...Shaw's group actually measured the rate of appearance of mutants for one drug, nevirapine, which inhibits reverse transcriptase...
...population of virus mutants replaces sensitive virus in as little as 14 to 28 days," Shaw said...
...Shaw sees this work as "the first step in what needs to be a series of studies." He believes that HIV and CD4 need to be correlated at all stages of infection, new drugs must be made to combat existing and new enzyme targets, and combinations of drugs must be tested...
...Combinations may cause enhancement of therapy," Shaw said. "One drug may cause the virus to mutate so that it becomes more susceptible to another drug...