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...years ago this week, on a warm July night, that a newborn lamb with an unique pedigree took her first breath in a small shed tucked in the Scottish hills a few miles south of Edinburgh. From the outside, she looked no different from thousands of other sheep born each summer on surrounding farms. But Dolly, as the world soon came to realize, was no ordinary lamb. She was cloned from a single mammary cell of an adult ewe, overturning long-held scientific dogma that had declared such a thing biologically impossible. Her birth set off a race in laboratories...

Author: /time Magazine | Title: The Perils of Cloning | 7/5/2006 | See Source »

...Those clones are born larger than normal and have trouble breathing in their first few weeks. Most of the surrogates that gave birth to them experience prolonged pregnancies and sluggish, difficult labors, which may have something to do with their distended and enlarged placentas. Some of Wilmut's cloned sheep were born with incomplete body walls, with muscles and skin around their abdomen that failed to properly join. Other scientists have reported abnormalities in kidney and brain function. In still other clones, the heart does not develop normally, and the walls that are supposed to separate fresh blood from deoxygenated...

Author: /time Magazine | Title: The Perils of Cloning | 7/5/2006 | See Source »

...biological mother than to those of a baby lamb. We will never know, though, whether her shortened telomeres would have shortened her life. In 2003 Wilmut and his team decided to put Dolly to sleep after she developed lung cancer caused by a viral infection common among sheep. An autopsy revealed that she was otherwise normal...

Author: /time Magazine | Title: The Perils of Cloning | 7/5/2006 | See Source »

...Jaenisch and Wilmut both see a role for cloning in treating human diseases--and perhaps someday conquering some of man's most intractable conditions. Wilmut and others have already created cow, sheep and pig cells genetically engineered to produce a particularly beneficial human protein, then cloned those cells to generate live animals able to make copious amounts of the target protein in their milk. It may be another 10 years or more before that approach yields anything safe and reliable enough to be used in real patients, and there is no guarantee that it will ever be successful...

Author: /time Magazine | Title: The Perils of Cloning | 7/5/2006 | See Source »

...hand fed by the farmer?s wife. So the lambs get used to people, and a lamb like that will come toward people because they are a source of food. Dolly had a similar situation; she did see a lot of people, an awful lot more than most sheep. And because we wanted her in a particular place to be photographed, she was often given extra food. So she got different by being spoiled and getting a lot of human attention...

Author: /time Magazine | Title: A Talk With Dolly's Creator | 7/3/2006 | See Source »

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