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...first to establish an association by studying depressed people who had also experienced a stressful life event, such as the death of a child or sudden unemployment. What Caspi's 2003 epidemiological study, published in Science, found was that people with one or two copies of the short allele of the gene appeared to be more vulnerable to depression after a stressful event than people without the gene. Subsequent studies have looked at 5-HTTLPR's role in related conditions such as posttraumatic stress disorder, anxiety and neuroticism - with mixed results...

Author: /time Magazine | Title: Study: 'Depression Gene' Doesn't Predict the Blues | 6/17/2009 | See Source »

...body of scientific evidence," says psychologist Caspi, who sent TIME.com an e-mail appended with 22 citations of studies that support his findings. "In the past six years, extensive research in experimental neuroscience using both animals and humans has validated the original report by showing that the 5-HTTLPR short allele-carriers are excessively vulnerable to stress," he says...

Author: /time Magazine | Title: Study: 'Depression Gene' Doesn't Predict the Blues | 6/17/2009 | See Source »

...Alexandre Todorov, a genetic epidemiologist at Washington University in St. Louis, Mo., whose 2007 peer-reviewed study was included in the JAMA piece. (While Todorov's study found an association between the gene and depression, it was based on a different variant - the long allele as opposed to the short one.) "If you have three studies and two find nothing and the third finds something significant, that does not mean that the third study is not real...

Author: /time Magazine | Title: Study: 'Depression Gene' Doesn't Predict the Blues | 6/17/2009 | See Source »

...short answer is: because he was invited. Russia is convening two back-to-back summits of significant global importance this week. Moscow is a key player in both the Shanghai Cooperation Organization (SCO), a Chinese-driven body aimed at improving ties with Russia and Central Asia, and the so-called BRIC group - a gang of four emerging world powers in Brazil, Russia, India and China. With the SCO and BRIC meeting at the same place, much of the non-Western world's geopolitical muscle is now rubbing shoulders in the shadow of the Urals. And the Iranian President, who never...

Author: /time Magazine | Title: Unbowed, Ahmadinejad Shows Up in Russia | 6/16/2009 | See Source »

...Washington, President Barack Obama said the disputed election revealed a change in expectations among voters and perhaps their leaders, but he stopped short of saying the balloting was rigged...

Author: /time Magazine | Title: Thousands Rally Again in Streets of Iran's Capital | 6/16/2009 | See Source »

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