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...drugs provided relief to 60% to 80% of patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

...university students to pour out 1 tsp. (5 ml) of cold medicine into kitchen spoons of various sizes. Consistently, the subjects botched the job, pouring out an average of 8% too little or 12% too much, depending on spoon size. Using a medium-size tablespoon they erred on the side of caution and tended to underdose. Using a large tablespoon, they overcompensated and overdosed. That is where the real danger lies. (See the most common hospital mishaps...

Author: /time Magazine | Title: A Spoonful of Medicine: Too Often the Wrong Dose | 1/7/2010 | See Source »

...Republican left who is willing to reach out across the aisle. The punishment for such comity is tea-party declarations of being a traitor: witness Lindsey Graham's second censure this week by a South Carolina County Republican Party for his bipartisan work on climate change. On the Democratic side, the death of Massachusetts' Ted Kennedy, the retirement of John Breaux of Louisiana and the loss of South Dakota's Tom Daschle, along with the bitter wounds from years of being in the minority, has left the party less open to cooperation. "The Senate is a nasty and brutish place...

Author: /time Magazine | Title: Senate Retirements Point to Dems' Uphill Election Fight | 1/7/2010 | See Source »

...restaurant whose published numbers are accurate down to the last calorie still may not give customers a truly realistic sense of what they're consuming. Every item on the menu, after all, has a separate calorie count, but many people pay attention mostly to the main course, piling on side dishes as something of an afterthought. Five of the restaurants in the survey even provided side dishes at no extra cost, and these added up to an average of 471 extra calories - exceeding the 443-calorie average of the entrees. "What they should be telling consumers," Roberts says, "is what...

Author: /time Magazine | Title: Dieters Beware: Calorie Counts Are Frequently Off | 1/6/2010 | See Source »

...risking the civil strife that would be spurred by any attempt to remove settlers from the West Bank. Israeli public opinion prevented Netanyahu from accepting the settlement-freeze demand, and the primary factor that brings him to the negotiating table may simply be the need to stay on side with Washington. (See 25 people who mattered...

Author: /time Magazine | Title: New Mideast Peace Talks: Back to the Treadmill? | 1/6/2010 | See Source »

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