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...Researchers would seek out potential drugs. Development teams would test and refine them in hopes of winning regulatory approval. Finally, marketers would peddle the approved drugs to physicians. These steps were typically conducted in isolation, so developers would sometimes find out too late that a candidate drug had terrible side effects or could not be mass-produced economically. Or marketers would discover late in the process that there wasn't much demand for the new drug they would soon be asked to sell...

Author: /time Magazine | Title: Drug Lord | 11/13/2007 | See Source »

Vasella changed all that. He had clinical researchers, chemists from production and marketing managers put their heads together to find profitable new uses for Sandostatin. Those exertions paid off. The drug won approval for treating the side effects of certain cancers, and sales rose rapidly, reaching $486 million last year. Vasella asked Kim Clark, then a Harvard Business School professor (and now dean), to sign on as a consultant. "He told me something that stuck in my mind," says Vasella. "He said, 'You can change an organization from top down or bottom up, but it's very hard to change...

Author: /time Magazine | Title: Drug Lord | 11/13/2007 | See Source »

That expansion was partly in preparation for the launch of a potential blockbuster drug called Zelnorm, aimed at irritable bowel syndrome, for which there are few treatments. But the FDA, expressing concern about Zelnorm's side effects, rejected the application, asking for more data. In the short term, says Morgan Stanley analyst Duncan Moore, Novartis' prospects for robust growth depend heavily on the FDA's reversing its ruling on Zelnorm and approving an anti-inflammatory drug named Prexige, which Novartis plans to submit to the agency toward the end of this year...

Author: /time Magazine | Title: Drug Lord | 11/13/2007 | See Source »

...adage in basketball is that defense wins championships. But anyone can tell you that at the end of the game, it’s the team with the most points that wins. The other side of the saying then, is that in addition to stopping the other team, you have to put your own numbers on the board. The Crimson thus turns to two rising stars to provide the offensive output needed to compete in the Ivy League. This season, juniors Drew Housman and Evan Harris will be counted on for an inside-outside presence. Their emergence is even more...

Author: By Lucas A. Paul, CONTRIBUTING WRITER | Title: BASKETBALL '07: More Than Just a 1-2 Punch | 11/13/2007 | See Source »

...this season. “It’s probably a bigger deal for [Amaker] and those players,” Harris says. “It’s got to be hard to play against the coach that recruited you.”With all of these side stories, the Dec. 1 matchup promises to be one of the most exciting of the season at Harvard. Amaker vs. former team. Harvard vs. big-time opponent. National television on ESPNU. Lavietes Pavilion is where the excitement will be. Is that where you?...

Author: By Kevin C. Reyes, CRIMSON STAFF WRITER | Title: BASKETBALL '07: Then and Now | 11/13/2007 | See Source »

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