Word: sides
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Dates: during 1990-1999
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...infected them alone, inserting the herpes gene into their nuclei. As this gene expressed itself, it made the tumor cells sensitive to the herpes drug ganciclovir. When the drug was then administered to the patient, says Anderson, it "made the tumor cells commit suicide." But here there were troublesome side effects...
Most researchers in the field agree that the adenovirus and retrovirus vectors are imperfect, to say the least. In addition to having immunological side effects, both lack the carrying capacity to accommodate the larger, more complex genes that would be useful in therapy. "There are only three problems in gene therapy," says Salk's Verma, "delivery, delivery and delivery. It isn't going to be a problem to make gene therapy work--if we have an appropriate set of tools to deliver the genes...
...Rodriguez (Michigan State, class of '04) has just learned that he has colon cancer. But he's not too concerned. Thanks to the genetic revolution that swept over the pharmaceutical industry 30 years earlier, scientists have developed a variety of anticancer drugs that work far better, and with fewer side effects, than the old poison-and-burn treatments of the late 20th century...
...same applies to cloning, which is really just the other side of the coin. True cloning, as first shown with Dolly the sheep two years ago, involves taking a developed cell and reactivating the genome within, resetting its developmental instructions to a pristine state. Once that happens, the rejuvenated cell can develop into a full-fledged animal, genetically identical to its parent...
Monica Mancini: On her eponymous debut album, Henry Mancini's daughter reveals a strong but sweet voice that rides a melody just so. The songs are Dad's--Moon River and others--with their mix of sophistication and schmaltz. Tart strings help keep Monica on the right side of the equation. The new label is PBS Records: music to drive Volvos...