Word: signaled
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Dates: during 1990-1999
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Nevertheless, the realization that dopamine may be a common end point of all those pathways represents a signal advance. Provocative, controversial, unquestionably incomplete, the dopamine hypothesis provides a basic framework for understanding how a genetically encoded trait--such as a tendency to produce too little dopamine--might intersect with environmental influences to create a serious behavioral disorder. Therapists have long known of patients who, in addition to having psychological problems, abuse drugs as well. Could their drug problems be linked to some inborn quirk? Might an inability to absorb enough dopamine, with its pleasure-giving properties, cause them to seek...
GAZA: Yasser Arafat is sending a strong signal that U.S. envoy Dennis Ross better come armed with concrete proposals to move peace talks forward when he arrives in the Middle East Tuesday. In a none-to-subtle push to get the Clinton Administration to aggressively work with Benjamin Netanyahu on a peace settlement, Arafat told reporters he didn't think Ross would bring any new suggestions to the table. "Naturally, the Palestinians are hoping the Americans will come with a fairly aggressive and dynamic proposal which will break the deadlock," reports TIME's Scot MacLeod. "But since this hasn...
...Republicans her refusal was a signal to go ballistic. Taking time from finalizing his loan with Bob Dole, House Speaker Newt Gingrich said Reno should explain under oath why she opposed a special counsel. Senate Judiciary Committee chairman Orrin Hatch, a sometime Reno supporter, was less bloodthirsty but no less unhappy. "There's overwhelming evidence that there may--that's all you've got to do, show that there may--have been criminal activity," he says. "You can't hide behind career prosecutors...
Even more daunting is the signal opposition to the outcome Big Tobacco most craves: freedom from future legal claims, a provision that would require an act of Congress. "No one is prepared to give the industry blanket immunity," says Matthew Myers, executive vice president of the National Center for Tobacco-Free Kids and a participant in the talks. Moreover, Myers adds, "this is a movie in mid-plot." The plot will thicken as negotiations continue this week...
Scientists have long known that morphine blunts that chain of pain reactions by preventing the spinal nerves from signaling the brain. But what they didn't know until the late 1980s is that these nerves are more than just glorified gatekeepers. They actually "remember" the body's past travails, causing permanent changes that are recorded in their molecular structure. "Think of the spinal cord as a voice-mail system," says neurobiologist Allan Basbaum of the University of California, San Francisco. "A message comes in and leaves something behind." The longer the injury persists, the more sensitive the spinal nerves become...