Word: sinclairism
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...researchers—who included Dudley Lamming, Oliver Medvedik, and Magda Latorre-Esteves, in addition to Sinclair—reveals that Sir2 does not serve this function alone. Rather, a group of related genes—the Sir2 family—plays a major role in regulating lifespan. Sinclair said that one of the genes in the family appears to control functions such as fat metabolism and cell survival, while another controls body temperature and the efficiency with which an organism uses energy, and yet others protect against diabetes...
...Sinclair said that he and his fellow researchers are in the process of establishing the individual purpose of each gene in order to determine which ones can be used for medicines. They are currently using one of the genes in the Sir2 family to protect mice from brain disorders analogous to Alzheimer’s disease, dementia, and Huntington’s Disease, he said...
...discovery of the Sir2 family came about after researchers realized that even organisms that did not contain the original Sir2 gene could have their lifespans extended by calorie restrictions, Sinclair explained. “These other genes take over,” he said...
According to Sinclair, the Sir2 genes are effective in extending lifespan because they control the body’s own defenses against disease—defenses which, he argued, modern medicine has not utilized to their full potentials...
...Sinclair said the power of the Sir2 family of genes could someday be harnessed to “stimulate the body to work harder and protect itself,” leading to a “whole new class of medicine that can treat many of the world’s diseases” including cancer, diabetes, Alzheimer’s, and even aging itself...