Word: siv
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Dates: during 1990-1999
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...first known case of human infection with simian immunodeficiency virus (SIV), a cousin of AIDS-causing HIV, has been documented in a laboratory worker. No one knows whether the virus, which isn't fatal in monkeys, will be deadly to humans, harmless or somewhere in between...
...Harvard researcher, Professor of Microbiology and Molecular Genetics Ronald C. Desrosiers, has been trying to develop such an animal model in monkeys with SIV, a rough equivalent of HIV in the animals. Desrosiers has been able to delete certain portions of SIV to create a live but weakened form of the virus which won't cause disease. Despite initial success with the strategy, later results have been disappointing...
...order to establish a high infection rate in newborn monkeys, the scientists exposed the animals to the simian immunodeficiency virus (SIV), whose behavior is similar to that of HIV, a virus which causes AIDS in humans. SIV was injected into the amniotic fluid, surrounding the fetus, during the late stages of pregnancy...
Ruprecht and her colleagues found that nearly all the monkeys tested positive for SIV-positive at birth. The results, Ruprecht said indicated that human babies whose mothers are HIV poaith's exposed to the virus late in the pregnancy or during actual delivery when the newborn comes in contact with skin or blood expose the fetus must come in contact with the amniotic find...
Daniel said researchers are now removing multiple genes from both SIV and HIV to determine how many deletions a virus can sustain before becoming ineffective as vaccines. By removing as many genes as possible, researchers hope to further decrease the chances of reverse mutation...