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After nearly a decade of setbacks and false starts, stem-cell science finally seems to be hitting its stride. Just a year after Japanese scientists first reported that they had generated stem cells by reprogramming adult skin cells - without using embryos - American researchers have managed to use that groundbreaking technique to achieve another scientific milestone. They created the first nerve cells from reprogrammed stem cells - an important demonstration of the potential power of stem-cell-based treatments to cure disease...
...Kevin Eggan at the Harvard Stem Cell Institute and Christopher Henderson at Columbia University, the 13-person team reported online today in Science Express that they had generated motor neurons from the skin cells of two elderly patients with a rare form of ALS, or Lou Gehrig's disease, a progressive neurodegenerative condition. The new study marks an important first step on the road toward real stem-cell-based therapies, and also answers several plaguing questions about the pioneering stem-cell technique known as induced pluripotent stem cell, or iPS, generation...
...first described by Japanese biologist Shinya Yamanaka, who, in 2007, showed that the introduction of four genes into an adult human skin cell could reprogram it back to an embryonic state (Yamanaka had reported the same achievement in mice the previous year). Like embryonic stem cells, these reprogrammed adult cells could be coaxed into becoming any other type of cell - from skin to nerve to muscle. But researchers questioned whether the new stem cells would behave as predictably or as safely as embryonic stem cells, or whether iPS would consistently yield usable cells. "Our work shows that the original method...
...feel really Asian in Ghana. Granted, the color of deeply polished ebony is the norm here, but I'm not even the glorious pale shade of ethereal white skin that can be seen on Ghanaian advertisements. I am pasty and yellow. I look strange to most Ghanaians—and they kindly tell...
...Police investigating Monday's heist suspect that two robbers were involved; one is thought to have dark hair, tan skin and a local accent, but no witnesses have yet come forward regarding the other...