Word: slamon
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...that cause them to grow abnormally. Eventually the cells develop into DCIS. The good thing about dcis cells is that they haven't spread beyond the milk duct. The bad thing is that they are malignant. "Some people call DCIS precancer, but it's not precancer," says Dr. Dennis Slamon, director of breast-cancer research at the UCLA School of Medicine. "It's preinvasive. It's cancer that hasn't invaded outside the breast ducts...
Herceptin is only a beginning, says UCLA's Slamon, who identified the HER2 receptor. There are bound to be other cancer proteins that pharmaceutical manufacturers can use as targets as they develop new, more selective drugs. "Using a combination of [these kinds of] therapies earlier in the disease could have a dramatic impact on outcomes," Slamon says...
...problem with having just one chemotherapy drug is that it limits your options. The cells that line the intestine are so used to acting as a garbage dump, explains Dr. Dennis Slamon of UCLA, that the ones "that eventually become malignant are less susceptible to chemotherapy...
...Bradfield's fellow guinea pigs in the initial study. But results of a just completed trial with 470 women do show it to be a significant improvement over chemo alone for women with this awful form of breast cancer. The details of the study will be revealed by Slamon this Sunday at a meeting in Los Angeles of the American Society of Clinical Oncology. Manufactured by Genentech under the name Herceptin, the drug is on a fast track for approval by the FDA, perhaps before year...
...library of tumor types, a long-range project called C-GAP (Cancer Genome Anatomy Project). But it will be years before this library can be put to practical use. "It took 20 years to make testing for hormone receptors routine in breast-cancer patients," notes UCLA's Slamon. It will take at least a decade to make testing for HER-2/neu, RAS and other genes routine for cancer patients in general...