Word: slye
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...famed breeders of mice are Professor Maud Slye of the University of Chicago and Dr. Clarence Cook Little of Jackson Memorial Laboratory at Bar Harbor, Me. Each has raised, killed and dissected more than 150,000 mice. Their purpose: to learn whether or not a tendency to cancer is inherited, and, if so, how. Dr. Slye has decided and firmly declared that cancer is genetically a recessive character which she can breed out of her mice and could, if given a stupendously free hand, breed out of human beings (TIME, Aug. 31). Dr. Little, less loudly, declares Dr. Slye...
Most authentic view of cancer is that it is not inheritable. But the susceptibility to cancer may be inherited. Dr. Maud Slye of Chicago, who was in Europe last week, says that the female offspring of mice which have cancer of the breast will also develop cancer of the breast (TIME, Aug. 31). Last week at Madison Dr. Madge Thurlow Macklin of London, Ont. declared that this inherited organ susceptibility applied to human beings too. Said Dr. Macklin, 43, plump, vivacious mother of three daughters, and the only woman taking part in the cancer symposium: "We find that the members...
...Miss Slye has autopsied 138,700 mice...
Firmly established is the Slye doctrine that susceptibility to cancer is inherited as a recessive Mendelian character, transmitted by a single gene. Resistance to the disease is a dominant character, and represses, but does not obliterate, the susceptibility factor whenever they occur together. A resistant individual mated to a susceptible one will have resistant offspring. But these offspring carry the susceptibility gene concealed in their germ plasm, and if they mate with susceptibles the second generation will be liable to cancer. The Slye mice show that not only inherited susceptibility but also some injury or chronic irritation is necessary...
Said Professor Slye last week before leaving: "If we had records for humans comparable to those for my mice, we could stamp out cancer in a generation. Sweden has made a start toward such records, but no other country in the world is making such an effort. Meanwhile, cancer is a leading cause of death, and as we make progress in heart diseases, it is likely to become the first cause in a comparatively short time...