Word: smartly
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...Many newer drugs target other pathways for tumor growth. Herceptin, introduced in 1998, interferes with a protein called epidermal growth factor by blocking the her2 receptor, a binding site that is found on the surface of many cells but is overabundant in about 25% of breast cancers. Other smart drugs interfere with the same growth factor, using slightly different chemical strategies to do so, and some have proved useful in a range of cancers. Gleevec, for example, which was approved in 2001, prevents growth factors from attaching to cancer cells and activating an enzyme called tyrosine kinase, which regulates cell...
...enterprising young American persuaded a "short, fat and ugly" tenor to record 10 arias in a Milan hotel room for 100 pounds. The singer was Enrico Caruso, and the album, a huge hit, gave rise to the classical recording industry. In The Life and Death of Classical Music the smart, crusty, blustery critic Norman Lebrecht frog-marches readers, prestissimo, through the glory days of Toscanini and Glenn Gould to the bloated collapse of the early 2000s, brought on by inflated contracts, corporate mismanagement, mindless rerecordings of the warhorses and a welter of weak-minded classical-lite crossover acts. The book...
...mail. "Now everybody has some kind of mobile device like that." To feed their growing digital appetites, Allen says, consumers want something even more powerful that can handle the spreadsheets, video, e-mail attachments and software that mobile phones can't deal with. Allen is betting that even a smart phone like Apple's won't have the computing power--or screen size--to satisfy users...
...Louisiana, as elsewhere, smart adaptation requires a lot more than good infrastructure and ecosystem management. Economic viability is also important, and that is not possible without insurance. In Louisiana and Florida, insurance companies responded to the burst of hurricanes in 2004 and 2005 by raising rates significantly, even canceling policies outright. How can hurricane-prone states retain coverage? "The only solution is to get the Federal Government to do what it did after September 11 and recognize that some risks are too large and costly for the private-insurance market to absorb on its own," says James Donelon, the state...
...culture over the past decade. But lately it seems every other punch line is about white people. Does he really think immigration can be reduced to "white people finding a loophole in slavery laws"--or was that a joke? Rock has demonstrated many times that he is smart. He doesn't need to stay trapped in the punch lines of the 1970s. The truth would be funnier and more helpful to us all. Bryce Ingman, LOS ANGELES...