Word: smarts
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Dates: during 2000-2009
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...That new perspective provided fertile ground for the growth of new classes of cancer therapies. While older drugs were like heavy artillery - obliterating cancer cells but causing lots of collateral damage - newer drugs are more like smart bombs. Some of them target communication signals within malignant cells, some cut off supply lines by interfering with the growth of blood vessels around a tumor, and others block the chemical agents that enable tumors to expand into new territory. These more targeted therapies tend to focus on frantically proliferating cancer cells while leaving healthy cells intact...
...Many newer drugs target other pathways for tumor growth. Herceptin, introduced in 1998, interferes with a protein called epidermal growth factor by blocking the her2 receptor, a binding site that is found on the surface of many cells but is overabundant in about 25% of breast cancers. Other smart drugs interfere with the same growth factor, using slightly different chemical strategies to do so, and some have proved useful in a range of cancers. Gleevec, for example, which was approved in 2001, prevents growth factors from attaching to cancer cells and activating an enzyme called tyrosine kinase, which regulates cell...
...enterprising young American persuaded a "short, fat and ugly" tenor to record 10 arias in a Milan hotel room for 100 pounds. The singer was Enrico Caruso, and the album, a huge hit, gave rise to the classical recording industry. In The Life and Death of Classical Music the smart, crusty, blustery critic Norman Lebrecht frog-marches readers, prestissimo, through the glory days of Toscanini and Glenn Gould to the bloated collapse of the early 2000s, brought on by inflated contracts, corporate mismanagement, mindless rerecordings of the warhorses and a welter of weak-minded classical-lite crossover acts. The book...
...mail. "Now everybody has some kind of mobile device like that." To feed their growing digital appetites, Allen says, consumers want something even more powerful that can handle the spreadsheets, video, e-mail attachments and software that mobile phones can't deal with. Allen is betting that even a smart phone like Apple's won't have the computing power--or screen size--to satisfy users...
...After all, the athletic (read: black) guys need to push the ball up the court and run one-on-one plays to showcase their skills. You can't hold them back by running that 1960s hayseed Princeton junk. Plus, only the smart, 1500-SAT (read: white) kids can learn those sets. The slower (read: very white) players need to milk the clock, move without the ball and throw those tricky backdoor passes to compete. So goes the code...