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...Parkinson’s disease is in the brains of patients themselves. As the illness worsens, brain tissue becomes clogged with a protein muck that includes a substance called alpha-synuclein. No one knows exactly what alpha-synuclein does, but it’s believed to play a role in the smooth transmission of nerve signals. When the substance clumps, it can’t do the work it was designed to do, leading to neuron damage, loss of the neurotransmitter dopamine, and eventually to the familiar shakiness of such well-known Parkinson’s sufferers as Janet Reno and Muhammed...

Author: /time Magazine | Title: Scary Cure | 12/18/2000 | See Source »

...only stirring up the Democrats and making it harder for Bush to govern when the time came. He hoped that Gore allies would be more likely to call for their man to step down if the Republicans weren't constantly doing so, and he wanted to smooth the way for the charm offensive he would launch as soon as Gore made it official--the calls to key Democrats that had to remain on hold until the struggle was over. "More than ever, a President-elect has a unique moment to seize," Bush told CBS on Tuesday. "And I'm going...

Author: /time Magazine | Title: Election 2000: Flipping The Script | 12/18/2000 | See Source »

...Martin's last album, Sound Loaded's production is somewhat overdone, and the vocals are often overwhelmed by the surging instrumentation. But through it all, Martin has a charm that's hard to deny. The women in his lyrics may be rough and ready, but Martin is always smooth...

Author: /time Magazine | Title: Music: Sound Loaded | 12/11/2000 | See Source »

...form as a producer, laying down beats for each number that are spare but never simplistic and that reverberate with menace, like footsteps following you down an alleyway late at night. The verbal flow on the album is involving and smooth; there's a smart mix of jokey lines ("In a room full of crackers/ I might cut the cheese," runs a passage on the track Redbull) and serious statements. A section on I Can't Go to Sleep laments, "Somebody raped our women/murdered our babieshit us with the crack and guns/in the early...

Author: /time Magazine | Title: Searching for the Perfect Beat | 12/11/2000 | See Source »

...this has been the way you were obliged to play the game. From a social point of view, innovation has been a case of having to take the occasionally rough with the generally smooth, partly because of the interactive nature of invention described above, and partly because for centuries we have lived in a directionless culture of scarcity. At no time was there either need or resources available to share the intellectual wealth beyond a select few. There was no point, for instance, in teaching literacy to the masses without an adequate number of printing presses to provide them with...

Author: /time Magazine | Title: Inventors & Inventions | 12/4/2000 | See Source »

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