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Narrow Range. The most glowing testimonial to amantadine's value came, ironically, from the U.S.S.R.'s most famous vaccine developer, Dr. Anatoli A. Smorodintsev. The drug was given, he reported, in reduced doses of 100 mg. daily to 10,000 Russians in Leningrad, a flu epidemic area. Half of them did not develop flu at all; most of those who did had cases that were milder than average. According to Smorodintsev, the side effects were negligible-though Soviet researchers have been known to soft-pedal side effects before...

Author: /time Magazine | Title: Virology: Drugs v. Vaccines | 6/27/1969 | See Source »

...couple of Russians named Smorodintsev and Nachaev recently figured out a way of preventing and treating influenza. Since influenza is contracted by breathing infective material, they reasoned, why not inhale serum from the blood of horses which have been immunized? In an article soon to appear in the American Journal of the Medical Sciences, Commander Albert P. Krueger of the University of California says that the Russians are right...

Author: /time Magazine | Title: Medicine: Influenza Through the Nose | 7/26/1943 | See Source »

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