Word: sodded
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Dates: during 1990-1999
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Klein cautioned that a large amount of research still lies ahead. SOD is just one player, albert "a bigger piece than we've ever had before," she said, but scientists are still searching for other altered genes responsible for cases of familial ALS not present in the current sample...
Brown said the research team will next look at three areas: analyzing SOD activity levels in affected patients, testing for free radical damage in patients and searching for drugs to eliminate free radicals...
...phone interview yesterday, Irwin Fridovich, a professor of bio chemistry at Duke University Medical Center, proposed several possible explanations for the increased susceptibility of neurons to decreased SOD levels in ALS patients...
Kunkel suggested that the extreme sensitivity and fragility of neurons to their environments could also cause increased susceptibility to low levels of SOD...
Fridovich said he anticipates that further experiments with the altered SOD will find the protein less active, and that accumulation of damage to cells caused by superoxides not eliminated by SOD could eventually cause the death of many cells...